Friday, May 4, 2012

Ketchup Used to Be Made of Fish: The Crazy History of The World's Greatest Condiment [Drawing Board]

Here's something that might just blow your mind: ketchup—the national condiment of 1896, according to the New York Tribune—wasn't always tomato based. In fact, if it had remained in its early form, we might be spreading fish paste on our burgers (gulp) instead of the tangy tomato-y goodness we presently rely on. More »


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Thursday, May 3, 2012

Tony Award Nominations 2012

The nominations for the 66th Annual Tony Awards have been announced and let me tell you it is quite a list. Some big name stars and some serious snubs comes out in the 2012 Tony Awards nominations. I am telling you I was surprised by some of the names on the list and some left off. That being said, I give to you the full list of nominations. Best Actor In A Play James Corden, One Man, Two Guvnors Philip Seymour Hoffman, Death of a Salesman James Earl Jones, Gore Vidal’s The Best Man Frank Langella, Man and Boy John Lithgow, The Columnist Best Actress In A Play Nina Arianda, Venus in Fur Tracie Bennett, End of the Rainbow Linda Lavin, The Lyons Stockard Channing, Other Desert Cities Cynthia Nixon, Wit Best Musical Newsies the Musical Once Leap of Faith Nice Work If You Can Get It Best Play Venus in Fur Clybourne Park Peter and the Starcatcher Other Desert Cities Best Revival Of A Play Death of a Salesman Gore Vidal’s The Best Man Master Class Wit Best Actor In A Musical Ron Raines, Follies Danny Burstein, Follies Jeremy Jordan, Newsies the Musical Steve Kazee, Once Norm Lewis, The [...]

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Recyclable Furniture Is What All Young Nomads Need [Genius]

Fact: Every time you move, you're going to throw a perfectly functional piece of furniture away. Maybe it's laziness, maybe its the distance involved, or maybe you just can't get rid of that ugly bookshelf. Either way, something inevitably ends up in the trash and you feel guilty. With SmartDeco Furnishing's cardboard-ish offerings, the transient souls of the world can depart knowing everything's recyclable. More »


brian williams

Wednesday, May 2, 2012

Number of US newborns with drug withdrawal triples

CHICAGO (AP) ? Less than a month old, Savannah Dannelley scrunches her tiny face into a scowl as a nurse gently squirts a dose of methadone into her mouth.

The infant is going through drug withdrawal and is being treated with the same narcotic prescribed for her mother to fight addiction to powerful prescription painkillers.

Disturbing new research says the number of U.S. babies born with signs of opiate drug withdrawal has tripled in a decade because of a surge in pregnant women's use of legal and illegal narcotics, including Vicodin, OxyContin and heroin, researchers say. It is the first national study of the problem.

The number of newborns with withdrawal symptoms increased from a little more than 1 per 1,000 babies sent home from the hospital in 2000 to more than 3 per 1,000 in 2009, the study found. More than 13,000 U.S. infants were affected in 2009, the researchers estimated.

The newborns include babies like Savannah, whose mother stopped abusing painkillers and switched to prescription methadone early in pregnancy, and those whose mothers are still abusing legal or illegal drugs.

Weaning infants from these drugs can take weeks or months and often requires a lengthy stay in intensive care units. Hospital charges for treating these newborns soared from $190 million to $720 million between 2000 and 2009, the study found.

The study was released online Monday in the Journal of the American Medical Association.

Savannah is hooked up to heart and oxygen monitors in an Oak Lawn, Ill., newborn intensive care unit. In a pink crib, she sleeps fitfully, sometimes cries all night, and has had diarrhea and trouble feeding ? typical signs of withdrawal. Some affected babies also have breathing problems, low birth weights and seizures.

It nearly breaks her young mother's heart.

"It's really hard, every day, emotionally and physically," said Aileen Dannelley, 25. "It's really hard when your daughter is born addicted."

Doctors say newborns aren't really addicted ? which connotes drug-seeking behavior that babies aren't capable of ? but their bodies are dependent on methadone or other opiates because of their mothers' use during pregnancy. Small methadone doses to wean them off these drugs is safer than cutting them off altogether, which can cause dangerous seizures and even death, said Dr. Mark Brown, chief of pediatrics at Eastern Maine Medical Center.

Newborn drug withdrawal is rampant in Maine, Florida, West Virginia, parts of the Midwest and other sections of the country.

Dr. Stephen Patrick, the lead author of the study and a newborn specialist at the University of Michigan health system in Ann Arbor, called the problem a "public health epidemic" that demands attention from policymakers, as well as from researchers to clarify what long-term problems these infants may face.

University of Maine scientist Marie Hayes said her research suggests some affected infants suffer developmental delays in early childhood, but whether those problems persist is uncertain.

It's the 21st century version of what was known as the "crack baby" epidemic of the 1980s. Some experts say that epidemic was overblown and that infants born to mothers using crack cocaine face no serious long-term health problems.

Some think the current problem is being overblown, too.

Carl Hart, an assistant psychiatry professor at Columbia University and a substance abuse researcher at the New York Psychiatric Institute, noted that only a tiny portion of the estimated 4 million U.S. infants born each year are affected.

Hart also said the study probably includes women who weren't abusing drugs during pregnancy, but were taking prescribed painkillers for legitimate reasons. He said he worries that the study will unfairly stigmatize pregnant women who are "doing the right thing" by taking methadone to fight their addiction.

Doctors pushing powerful painkillers "like candy" contribute to the problem, said Arturo Valdez, who runs the Chicago substance abuse program that Aileen Dannelley attends. Patients at his West Side clinic include men and women who are prescribed opiate painkillers for legitimate reasons, such as car accident injuries, and find themselves addicted when the prescriptions runs out. Some turn to street drugs, which can be cheaper and easier to obtain, Valdez said.

In some states, mothers of newborns with drug withdrawal are arrested and jailed, but Valdez said addiction is a brain disease that should be treated like other illnesses, not stigmatized.

Aileen Dannelley said she started abusing drugs after an adult neighbor introduced her to crack when she was 14. She said she would "never have touched it" if she had known how addictive drugs can be.

She said she has abused Vicodin, which a doctor gave her to treat back pain from sitting all day at an office job, as well as other prescription painkillers and heroin.

Dannelley was still abusing drugs early in her pregnancy but decided in December to quit, vowing: "I'm not going to go back to that lifestyle. There's a baby inside me."

Now she is trying to get her life back on track. Estranged from her husband, she is living with her parents and just signed up for nursing classes at a local junior college. She visits Savannah every day. The baby has been in the hospital since she was born in early April, and her mother hopes to take her home soon.

"I am doing so good for the first time in my life," Dannelley said.

___

Online:

JAMA: http://jama.ama-assn.org

Methadone information: http://1.usa.gov/n6b5Fn

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Easy Car Loans - Guaranteed Car Financing With Low APR | Car ...

These days mobility has become such a necessity in one?s life that it has become unimaginable to even pass one day. At the same time maintaining a car is even more challenge. The car is such a thing that requires day to day maintenance, yet the condition of your car start detraining with each day passing. Not only that but its price also states falling rather the moment you bring your car out of dealers garage the price deprecates. Under the circumstances the only way left with owner is to refinance his car before he gets in such a position that he may not be able to get a similar model again especially if he is running in bad credit situation. Here the big question arises in one?s mind how do I get a car loan without any credit history? There are no credit check auto finance dealers in the market who offer you certain options where car loans for people with no credit history becomes quite possible.

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If you are confronted with such situation and you desperately need a car also then it is suggested to wait for some time and try to improve your credit rating, or ask you parents or may be guardians to perform as guarantor as co signer and make your deal easy. That way your need will be met and you will also built a habit of full time worker. The comparison of the auto loan lender is also very important thing that every costumer should do no matter what. They should not fear about the time as it is completely worth the time that you spend.


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Tuesday, May 1, 2012

Scientists find gene that inhibits pancreas cancer spread | The Raw ...

By Agence France-Presse
Sunday, April 29, 2012 15:20 EDT

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PARIS ? Scientists have identified a gene that slows the spread of pancreatic cancer tumours, paving the way for targeted treatment of one of the deadliest forms of the disease, said a paper published Sunday.

After discovering the gene dubbed USP9X at work in a study of pancreatic cancer in mice, the international research team found it also played a role in humans.

?We looked in human tumour specimens and we found that it was missing in a fraction of patients ? the patients that did very poorly ? the people who died the fastest,? researcher David Tuveson told AFP.

?Patients that had a low level of the gene expressed ? they died very quickly after their operation and the patients who at the end of their life had lots of metastasis (spreading of the cancer), they had also a very low level of this protein.?

The existence of the gene, which is found in all of our cells but goes missing in some tumours, was known before but not its role as a cancer suppressor, said Tuveson.

Three other pancreatic tumour suppressor genes are known to exist, but this is the one whose absence ?probably causes metastasis ? that is what kills people with pancreas cancer,? said the scientist.

The discovery means that ?we can wake up the gene by using drugs? known as epigenetic modulators, he added.

?Our observation allows us to potentially treat people that have lost this gene in the pancreas tumours. It allows us to offer a therapy for the patients that actually have the worst prognosis.?

Tuveson said these kinds of drugs have already been developed, ?but people haven?t figured out where exactly they would be useful.

?We are proposing that these drugs would be useful in this subset of pancreas cancer patients.?

Pancreatic cancer kills about 96 percent of its victims within five years of diagnosis, one of the lowest cancer survival rates.

Early diagnosis is difficult, so the disease is often discovered only after it has already spread.

Agence France-Presse

AFP journalists cover wars, conflicts, politics, science, health, the environment, technology, fashion, entertainment, the offbeat, sports and a whole lot more in text, photographs, video, graphics and online.

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Getting All You Need at Dicks Sporting Goods

If you are looking to get ready for your next sports season, you might want to try and find dicks sporting goods coupons to help you bring the cost of all your equipment down to fit within your budget. No matter what sport you are going to be playing in, there is always something that you can buy to help you improve your performance. For example, if you are a track runner you need to make sure that you have the right shoes for the events that you are participating in. If you are a basketball player, shoes, ankle braces and even sweat bands can help you make sure that you are playing as safely as you possibly can. Whatever you need to get, a coupon can help you bring the cost down to a more manageable level. It shouldn?t even take too long to find a great deal as well.

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